9KL2
Crystal structure of Pleurocybella porrigens lectin (PPL) in complex with GalNAc
Summary for 9KL2
| Entry DOI | 10.2210/pdb9kl2/pdb |
| Descriptor | Lectin, 2-acetamido-2-deoxy-alpha-D-galactopyranose, NITRATE ION, ... (4 entities in total) |
| Functional Keywords | trefoil, lectin, sugar binding protein |
| Biological source | Pleurocybella porrigens |
| Total number of polymer chains | 3 |
| Total formula weight | 44724.99 |
| Authors | Adachi, D.,Ishimoto, N.,Kawabata, H.,Mizutani, K.,Park, S.-Y.,Tame, J.R.H.,Kamata, K. (deposition date: 2024-11-14, release date: 2025-11-19, Last modification date: 2025-12-31) |
| Primary citation | Adachi, D.,Ishimoto, N.,Mizutani, K.,Takahashi, K.,Kubota, R.,Kawabata, H.,Park, S.Y.,Vandebroek, L.,Voet, A.R.D.,Yamada, M.,Ozeki, Y.,Fujii, Y.,Fujita, H.,Tame, J.R.H.,Kamata, K. Crystal and Cryo-EM structure of PPL, a novel hexameric R-type lectin from the poisonous mushroom Pleurocybella porrigens. Glycobiology, 36:-, 2025 Cited by PubMed Abstract: Pleurocybella porrigens is a mushroom that grows widely around the temperate northern hemisphere, and was once considered edible, especially in Japan. Following a number of deaths in 2004, investigations revealed the presence of various toxins, including a lectin (PPL) that apparently survives cooking and enters the bloodstream via the stomach. We have cloned PPL and solved its structure by X-ray crystallography and cryo-EM. We report the sugar binding properties of this β-trefoil lectin, which has a novel hexameric structure. PubMed: 41342409DOI: 10.1093/glycob/cwaf082 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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