9KG8

Solution structure of the 2:1 berberine- hTERT-G4 complex

Summary for 9KG8

• Entry DOI: 10.2210/pdb9kg8/pdb
• Descriptor: DNA (5'-D(*AP*AP*AP*GP*GP*GP*TP*CP*GP*GP*GP*AP*CP*TP*GP*GP*GP*CP*GP*GP*GP*GP*TP*T)-3'), BERBERINE (2 entities in total)
• Functional Keywords: htert promoter, g-quadruplex, nmr solution structure, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 8244.58

Authors

Wang, K.B. (deposition date: 2024-11-08, release date: 2026-06-03)

• Primary citation: Zhang, Y.Q.,Gu, W.,He, S.H.,Cheng, R.S.,Chen, Z.Y.,Yan, T.D.,Kong, L.Y.,Wang, K.B.; G146A Mutation in hTERT Promoter Induces a Distinct G-Quadruplex That Activates hTERT Transcription: Structure Determination and Its Potential as a Drug Target; To Be Published,

Experimental method

SOLUTION NMR