9KCC

DNA duplex containing copper-mediated 5-fluorouracil-cytosine base pairs

Summary for 9KCC

• Entry DOI: 10.2210/pdb9kcc/pdb
• Descriptor: DNA (5'-D(*GP*GP*AP*CP*CP*CP*(UFP)P*GP*GP*TP*CP*C)-3'), COPPER (II) ION (2 entities in total)
• Functional Keywords: metal-mediated base pair, copper, 5-fluorouracil, dna
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 3706.88

Authors

Kondo, J.,Hirabayashi, K.,Torigoe, H.,Adachi, S. (deposition date: 2024-11-01, release date: 2025-09-10)

Primary citation

Torigoe, H.,Hirabayashi, K.,Adachi, S.,Kondo, J.
Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA.
Dalton Trans, 54:7208-7213, 2025

PubMed Abstract: Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C-Cu-FdU and FdU-Cu-C base pairs.

PubMed: 40265694
DOI: 10.1039/d5dt00619h

Experimental method

X-RAY DIFFRACTION (2.31 Å)