9K95

Cryo-EM structure of human gamma-secretase in complex with compound E

This is a non-PDB format compatible entry.

Summary for 9K95

• Entry DOI: 10.2210/pdb9k95/pdb
• EMDB information: 62188
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: intramembrane protease, gamma-secretase, presenilin-1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 179843.91

Authors

Zhou, R.,Huang, G.,Guo, X.,Wang, J.,Ge, X.,Shi, Y. (deposition date: 2024-10-25, release date: 2025-10-29)

• Primary citation: Zhou, R.,Huang, G.,Guo, X.,Wang, J.,Ge, X.,Shi, Y.; Structural insights into human signal peptide peptidase; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.9 Å)