9K91

Cryo-EM structure of human histone deacetylase 6 tandem catalytic domain (HDAC6 CD1-2)

Summary for 9K91

• Entry DOI: 10.2210/pdb9k91/pdb
• EMDB information: 62184
• Descriptor: Histone deacetylase 6, ZINC ION (2 entities in total)
• Functional Keywords: deacetylase, metalloenzyme, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 84266.15

Authors

Sun, C.,Xie, K.,Zhu, Z.,Chao, Y.,Zhou, Z.,Qu, Q.,Zhu, Y. (deposition date: 2024-10-25, release date: 2026-07-15)

• Primary citation: Sun, C.,Wang, Y.,Cai, S.,Xie, K.,Li, M.,Zhu, Z.,Chao, Y.,Zhou, Z.,Chen, Y.,Xue, W.,Mu, X.,Bian, X.,Miao, W.,Wu, J.,Ding, Q.,Wang, M.,Tao, B.,Zhang, I.,Zhu, Y.,Qu, Q.,Zhu, Y.; Hydrogen sulfide binds to the zinc-active-site of hHDAC6 to increase enzyme activity via an H2S-mediated deacetylation pathway; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.86 Å)