9JV3

Structure of Human HDAC2

Summary for 9JV3

• Entry DOI: 10.2210/pdb9jv3/pdb
• Descriptor: Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (9 entities in total)
• Functional Keywords: histone deacetylase 2, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 140500.92

Authors

Tojo, T.,Itoh, Y.,Kurohara, T.,Li, Y.,Singh, R.,Narozny, R.,Wiel, A.,Miyake, Y.,Yamashita, Y.,Kusakabe, K.,Uchida, S.,Suzuki, T. (deposition date: 2024-10-08, release date: 2025-10-08)

• Primary citation: Tojo, T.,Itoh, Y.,Kurohara, T.,Li, Y.,Singh, R.,Narozny, R.,Wiel, A.,Miyake, Y.,Yamashita, Y.,Kusakabe, K.,Uchida, S.,Suzuki, T.; Discovery of an HDAC2-selective inhibitor based on enzyme-inhibitor binding thermodynamics and kinetics, and its potential as a therapeutic drug for neurological disorders; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.57 Å)