9JLN

Cryo-EM structure of human TauT in presence of taurine, observed only one sodium ion, determined in an inward-occluded conformation

Summary for 9JLN

Entry DOI	10.2210/pdb9jln/pdb
EMDB information	61591
Descriptor	Sodium- and chloride-dependent taurine transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (6 entities in total)
Functional Keywords	huamn taurine transporter, transmembrane protein, inward-occluded conformation, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	70803.38
Authors	Qu, Q.,Chao, Y.,Zhou, Z. (deposition date: 2024-09-19, release date: 2025-03-19, Last modification date: 2025-05-07)
Primary citation	Chao, Y.,Zhou, Z.,Xia, H.,Yang, C.,Li, T.,Tang, Y.Q.,Shu, Y.,Ba, Q.,Hong, J.,Li, D.,Qu, Q. Transport and inhibition mechanism for human TauT-mediated taurine uptake. Cell Res., 35:381-384, 2025 Cited by PubMed: 39837997 DOI: 10.1038/s41422-025-01076-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation