9JKP
Crystal structure of the Staphylococcus aureus GTPase Era in complex with GDP
Summary for 9JKP
| Entry DOI | 10.2210/pdb9jkp/pdb |
| Descriptor | GTPase Era, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | ribosome, maturation, gtpase, rna binding protein |
| Biological source | Staphylococcus aureus (strain NCTC 8325 / PS 47) |
| Total number of polymer chains | 1 |
| Total formula weight | 34847.25 |
| Authors | Klochkova, E.,Biktimirov, A.,Islamov, D.,Belousov, A.,Yusupov, M.,Usachev, K. (deposition date: 2024-09-16, release date: 2024-12-18) |
| Primary citation | Klochkova, E.,Biktimirov, A.,Islamov, D.,Belousov, A.,Validov, S.,Yusupov, M.,Usachev, K. Crystal structure of the GDP-bound GTPase Era from Staphylococcus aureus. Biochem.Biophys.Res.Commun., 735:150852-150852, 2024 Cited by PubMed Abstract: GTPase Era from Staphylococcus aureus belongs to the TRAFAC superfamily of the TrmE-Era-EngA-EngB-Septin-like GTPases class and plays a significant role in the vital activity of this pathogenic microorganism as a maturation factor of the 30S ribosome subunit. However, the functions of this protein are not fully understood, making it a promising object for further study. Here, the 2.76 Å resolution crystal structure of Staphylococcus aureus Era in complex with GDP is presented. Structural comparison with other GTP-bound and GDP-bound homologous proteins, GTPase domain and the KH domain revealed a mutual orientation in S. aureus which has not been described before. The GDP-bound Era structure presented here will facilitate efforts to elucidate its interactions with its regulators and lay the foundation for a structure-based search for specific inhibitors. PubMed: 39432921DOI: 10.1016/j.bbrc.2024.150852 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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