9JIO

Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab H4

Summary for 9JIO

• Entry DOI: 10.2210/pdb9jio/pdb
• EMDB information: 61512
• Descriptor: Secreted protein ORF2, H4 Fab heavy chain, H4 Fab light chain (3 entities in total)
• Functional Keywords: hepatitis e virus, capsid protein, e2s domain, immune complex, h4 antibody, viral protein/immune system, viral protein-immune system complex
• Biological source: Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1); More
• Total number of polymer chains: 6
• Total formula weight: 97919.07

Authors

Liu, L.,Zheng, Q.,Li, S. (deposition date: 2024-09-12, release date: 2025-07-23, Last modification date: 2025-11-05)

Primary citation

Chen, Z.,Liu, L.,Situ, J.,Li, G.,Guo, S.,Lai, Q.,Wu, S.,Jiang, Y.,Fan, J.,Tang, Z.,Li, Y.,Wen, G.,Wang, S.,Ying, D.,Liang, Y.,Siu-Fung Ho, S.,Ma, X.,Yiu-Hung Tsoi, J.,Shun, E.H.,Chew, N.F.,Ma, W.,Mao, W.,Li, T.,Chen, Z.,Fang, M.,Wang, Y.,Yu, H.,Zhang, F.,Zhang, A.J.,Li, S.,Xia, N.,Sridhar, S.,Zheng, Q.,Zheng, Z.
Antibodies elicited by hepatitis E vaccination in humans confer cross-genus protection against rat hepatitis E virus.
J Hepatol, 83:1046-1056, 2025

PubMed Abstract: Paslahepevirus balayani (bHEV), also known as hepatitis E virus (HEV), encompasses eight genotypes, five of which infect humans. Rats are natural reservoirs of Rocahepevirus ratti genotype 1 (HEV-r-1; rat HEV; rHEV), which has recently been implicated in viral hepatitis. Despite the antigenic divergence between bHEV and rHEV, studies on shared protective antibodies remain rare.

PubMed: 40571163
DOI: 10.1016/j.jhep.2025.06.015

Experimental method

ELECTRON MICROSCOPY (2.87 Å)