9J2W

Human cGAS catalytic domain bound with XL-3156

This is a non-PDB format compatible entry.

Summary for 9J2W

• Entry DOI: 10.2210/pdb9j2w/pdb
• Descriptor: Cyclic GMP-AMP synthase, 2-(1~{H}-benzimidazol-2-yl)-4-[[1-(1~{H}-benzimidazol-2-yl)-3-methyl-5-oxidanyl-pyrazol-4-yl]-pyridin-2-yl-methyl]-5-methyl-pyrazol-3-ol, ZINC ION, ... (4 entities in total)
• Functional Keywords: cgas, inhibitor, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86684.44

Authors

Zhao, W.F.,Li, M.J.,Xu, Y.C. (deposition date: 2024-08-07, release date: 2025-06-04)

• Primary citation: Zhao, W.F.,Xu, Y.C.; Discovery of novel cGAS inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)