9IRL

Crystal structure analysis of LW-Srci-2o in complex with c-Src.

This is a non-PDB format compatible entry.

Summary for 9IRL

• Entry DOI: 10.2210/pdb9irl/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, (2~{R})-2-[3,5-bis(fluoranyl)phenyl]-2-[2-chloranylethanoyl(cyclopropyl)amino]-~{N}-cyclopentyl-ethanamide (3 entities in total)
• Functional Keywords: covalent inhibitor, c-src kinase, allosteric pocket, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 51963.22

Authors

Xu, D.,Huiming, Z.,Hongchan, H. (deposition date: 2024-07-16, release date: 2025-07-16)

• Primary citation: Xu, D.; Structure-based development of selective covalent inhibitors targeting a dynamic allosteric pocket of c-Src kinase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.031 Å)