9IPO

Hemichannel sub-structure of Cx36/GJD2 gap junction intercellular channel (FN conformation) in soybean polar lipid nanodiscs, treated with a 10-fold molar excess of carbenoxolone

Summary for 9IPO

Entry DOI	10.2210/pdb9ipo/pdb
EMDB information	60774 60779
Descriptor	Gap junction delta-2 protein,Soluble cytochrome b562, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, TETRADECANE (3 entities in total)
Functional Keywords	gap junction, connexin36, inhibitor, carbenoxolone, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	257918.74
Authors	Jang, H.S. (deposition date: 2024-07-11, release date: 2026-01-21)
Primary citation	Lee, C.W.,Jang, H.S.,Woo, J.S. Structural insights into the closing mechanism of gap junction intercellular channels by carbenoxolone To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.41 Å)

Structure validation