9IPN

Hemichannel sub-structure of Cx36/GJD2 gap junction intercellular channel (FN conformation) in soybean polar lipid nanodiscs, treated with a 10-fold molar excess of carbenoxolone and incubated shortly

Summary for 9IPN

• Entry DOI: 10.2210/pdb9ipn/pdb
• EMDB information: 60763 60778
• Descriptor: Gap junction delta-2 protein,Soluble cytochrome b562, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, TETRADECANE (3 entities in total)
• Functional Keywords: gap junction, connexin36, inhibitor, carbenoxolone, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 251470.48

Authors

Jang, H.S. (deposition date: 2024-07-11, release date: 2026-01-21)

• Primary citation: Lee, C.W.,Jang, H.S.,Woo, J.S.; Structural insights into the closing mechanism of gap junction intercellular channels by carbenoxolone; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.46 Å)