9IP9

Poly-alanine model for HL-type bispecific diabody Ex3 composed of 528 and OKT3 Fvs in ternary complex with sEGFR and CD3gamma-epsilon (middle conformation)

Summary for 9IP9

• Entry DOI: 10.2210/pdb9ip9/pdb
• EMDB information: 60766
• Descriptor: Epidermal growth factor receptor, HL-type bispecific diabody Ex3, T-cell surface glycoprotein CD3 gamma chain,T-cell surface glycoprotein CD3 epsilon chain (3 entities in total)
• Functional Keywords: bispecific antibody, diabody, egfr, cd3, ternary complex, hl, ex3, 528, okt3, antitumor protein, antitumor protein-immune system complex, antitumor protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 149218.36

Authors

Sato, K.,Uehara, S.,Tsugita, A.,Matsui, T.,Asano, R.,Makabe, K.,Yokoyama, T.,Tanaka, Y. (deposition date: 2024-07-10, release date: 2025-05-28)

• Primary citation: Sato, K.,Uehara, S.,Tsugita, A.,Ishii, M.,Ishiyama, S.,Maejima, A.,Nakahara, I.,Nazuka, M.,Matsui, T.,Christos, G.,Yokoyama, T.,Kumagai, I.,Makabe, K.,Asano, R.,Tanaka, Y.; Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement; Cell Rep, 2025

Experimental method

ELECTRON MICROSCOPY (3.64 Å)