9INV

Crystal structure of DAPK1 in complex with isoliquiritigenin

Summary for 9INV

Entry DOI	10.2210/pdb9inv/pdb
Descriptor	Death-associated protein kinase 1, 2',4,4'-TRIHYDROXYCHALCONE, SULFATE ION, ... (4 entities in total)
Functional Keywords	dapk1, kinase, inhibitor, isoliquiritigenin, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34148.72
Authors	Yokoyama, T. (deposition date: 2024-07-08, release date: 2024-10-09)
Primary citation	Yokoyama, T.,Hisatomi, K.,Oshima, S.,Tanaka, I.,Okada, T.,Toyooka, N. Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor. Eur.J.Med.Chem., 279:116836-116836, 2024 Cited by PubMed: 39243455 DOI: 10.1016/j.ejmech.2024.116836 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation