9IMA

Cryo-EM structure for the GPRC5D complexed with Talquetamab Fab

Summary for 9IMA

• Entry DOI: 10.2210/pdb9ima/pdb
• EMDB information: 60686
• Descriptor: Talquetamab Fab (anti-GPRC5D) Heavy chain, Talquetamab Fab (anti-GPRC5D) Light chain, G-protein coupled receptor family C group 5 member D, ... (4 entities in total)
• Functional Keywords: talquetamab, class c gpcr, multiple myeloma, bispecific antibody, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 4
• Total formula weight: 130203.43

Authors

Jeong, J.,Shin, J.,Park, J.,Cho, Y. (deposition date: 2024-07-02, release date: 2024-09-11)

• Primary citation: Jeong, J.,Park, J.,Young Mo, G.,Shin, J.,Cho, Y.; Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma.; J.Mol.Biol., 436:168748-168748, 2024; PubMed: 39181182; DOI: 10.1016/j.jmb.2024.168748

Experimental method

ELECTRON MICROSCOPY (2.65 Å)