9IG1

Crystal structure of Kalirin/Rac1 in complex with DK-652

This is a non-PDB format compatible entry.

Summary for 9IG1

• Entry DOI: 10.2210/pdb9ig1/pdb
• Descriptor: Ras-related C3 botulinum toxin substrate 1, Kalirin, 2-chloranyl-~{N}-(1-oxidanylidene-2~{H}-isoquinolin-7-yl)ethanamide, ... (4 entities in total)
• Functional Keywords: gtpase, guanine nucleotide exchange factor, complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 41003.61

Authors

Gray, J.L.,Zaidman, D.,Callens, M.C.,von Delft, F.,London, N.,Brennan, P.E. (deposition date: 2025-02-18, release date: 2026-03-04)

• Primary citation: Gray, J.L.,Callens, M.C.,Zaidman, D.,von Delft, F.,London, N.,Brennan, P.E.; Discovery of covalent inhibitors of the Kalirin/Rac1 GEF/GTPase complex.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)