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9IAM

Structure of cyclodipeptide synthase from Nocardia brasiliensis (Nbra-CDPS) in complex with alanylated RNA microhelices analogues mimicking Ala-tRNA-Ala substrate

This is a non-PDB format compatible entry.
Summary for 9IAM
Entry DOI10.2210/pdb9iam/pdb
Related9I5M
DescriptorCyclodipeptide synthase, RNA (5'-R(P*GP*GP*GP*GP*CP*UP*AP*UP*UP*CP*GP*UP*AP*GP*CP*UP*CP*CP*AP*CP*C)-3') (2 entities in total)
Functional Keywordsnonribosomal peptide synthetases, cyclodipeptide synthases, ligase, trna, rna binding protein
Biological sourceNocardia brasiliensis ATCC 700358
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Total number of polymer chains19
Total formula weight432986.38
Authors
Marouf, Z.,Charbonnier, J.B.,Fernandez Varela, P.,Legrand, P. (deposition date: 2025-02-11, release date: 2026-03-11)
Primary citationMarouf, Z.,Charbonnier, J.B.,Fernandez Varela, P.,Lescop, E.,Morellet, N.,Gondry, M.
The tRNA moieties of two consecutive substrates of a cyclodipeptide synthase share a common binding site as demonstrated with RNA microhelices that mimic their acceptor arms.
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.61 Å)
Structure validation

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PDB entries from 2026-03-11

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