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9IAL

Structure of cyclodipeptide synthase from Nocardia brasiliensis (Nbra-CDPS) in complex with RNA microhelices mimicking tRNA-Glu acceptor arm

Summary for 9IAL
Entry DOI10.2210/pdb9ial/pdb
Related9I5M
DescriptorCyclodipeptide synthase, RNA (5'-R(P*GP*UP*CP*CP*CP*CP*UP*UP*UP*CP*GP*AP*GP*GP*GP*GP*AP*CP*GP*CP*CP*A)-3'), PHOSPHATE ION (3 entities in total)
Functional Keywordsnonribosomal peptide synthetases cyclodipeptide synthases ligase, trna acceptor arm, rna binding protein
Biological sourceNocardia brasiliensis ATCC 700358
More
Total number of polymer chains6
Total formula weight128374.92
Authors
Marouf, F.Z.,Charbonnier, J.B.,Fernandez Varela, P. (deposition date: 2025-02-11, release date: 2026-03-04)
Primary citationMarouf, F.Z.,Charbonnier, J.B.,Fernandez Varela, P.,Lescop, E.,Morellet, N.,Gondry, M.
The tRNA moieties of two consecutive substrates of a cyclodipeptide synthase share a common binding site as demonstrated with RNA microhelices that mimic their acceptor arms.
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.43 Å)
Structure validation

250835

PDB entries from 2026-03-18

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