9I8L

X-ray structure of a polyoxidovanadate/lysozyme adduct obtained when the protein is treated with [VIVO(acac)2] at 310 K

Summary for 9I8L

Entry DOI	10.2210/pdb9i8l/pdb
Descriptor	Lysozyme C, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
Functional Keywords	pov, protein, vanadium, polyoxidovanadate, metal protein interaction, hydrolase
Biological source	Gallus gallus (chicken)
Total number of polymer chains	1
Total formula weight	17516.50
Authors	Tito, G.,Ferraro, G.,Merlino, A. (deposition date: 2025-02-05, release date: 2025-05-14, Last modification date: 2025-06-18)
Primary citation	Tito, G.,Ferraro, G.,Garribba, E.,Merlino, A. Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37°C Upon Reaction of V IV O(acetylacetonato) 2 With Lysozyme. Chemistry, 31:e202500488-e202500488, 2025 Cited by PubMed Abstract: Crystals of the model protein lysozyme were grown and soaked with the potential drug VO(acetylacetonato) at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature. PubMed: 40271720 DOI: 10.1002/chem.202500488 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.831 Å)

Structure validation