9I5S
Solution structure of an intramolecular anti-parallel G-quadruplex with a 5'-end overhang.
Summary for 9I5S
| Entry DOI | 10.2210/pdb9i5s/pdb |
| NMR Information | BMRB: 34978 |
| Descriptor | Human telomeric DNA G-quadruplex hteloS1[11] (1 entity in total) |
| Functional Keywords | g-quadruplex, dna, telomere |
| Biological source | Homo sapiens |
| Total number of polymer chains | 1 |
| Total formula weight | 7670.78 |
| Authors | |
| Primary citation | Avendano Avila, C.,Heddi, B. An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction. Chem.Commun.(Camb.), 61:17661-17664, 2025 Cited by PubMed Abstract: G-quadruplex structures formed by human telomeric sequences are highly sensitive to subtle sequence variations and local environment. While most structural studies have focused on sequences containing four uninterrupted G-tracts, the structural consequences of splitting a G-tract remain unexplored. Here, we present the NMR solution structure of a human telomeric sequence with the first G-tract split. The structure adopts an antiparallel topology with a disordered GTT segment at the 5'-end. This conformation is preferentially formed at a biologically relevant double-strand/single-strand DNA junction. These findings broaden our understanding of the structural diversity of human telomeric G-quadruplexes. PubMed: 41099088DOI: 10.1039/d5cc03633j PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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