9I5N

Single particle cryo electron microscopy of a Fab fragment bound to recombinant human CD40 ligand

Summary for 9I5N

Entry DOI	10.2210/pdb9i5n/pdb
EMDB information	52634
Descriptor	Fab20 heavy chain, Fab20 light chain, CD40 ligand, soluble form, ... (5 entities in total)
Functional Keywords	cd40 ligand inhibitor, cd154 inhibitor, autoimmunity, fab fragment, immune system
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	40134.12
Authors	Kristoffersen, E.L.,Schinkel, T.,Andersen, E.S. (deposition date: 2025-01-28, release date: 2026-02-25)
Primary citation	Pedersen, K.,Laursen, N.S.,Green, K.,Hansen, A.G.,Palarasah, Y.,Rovsing, A.B.,Kristoffersen, E.L.,Schinkel, T.,Andersen, E.S.,Valero, J.,Civit, L.,Troldborg, A.,Degn, S.E.,Thiel, S. Curbing Autoimmunity: A Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation Eur.J.Immunol., 2026 Cited by DOI: 10.1002/eji.70158 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation