9I5E

A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery

9I5E の概要

• エントリーDOI: 10.2210/pdb9i5e/pdb
• EMDBエントリー: 52628
• 分子名称: Isoform 2B of GTPase KRas,APH2, Nanobody 26, {(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-[(2S)-2-fluoropropanoyl]piperazin-2-yl}acetonitrile, ... (5 entities in total)
• 機能のキーワード: cryoem imaging scaffold, cancer, gtpase, nanobodies, coiled-coil, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76196.29

構造登録者

Samson, C.,Dossou, I.,Steinmetz, A.,Kumar, A.,Mathieu, M.,Rak, A. (登録日: 2025-01-28, 公開日: 2025-11-12)

• 主引用文献: Samson, C.,Dossou, I.,Steinmetz, A.,Kumar, A.,Mathieu, M.,Rak, A.; A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery; To Be Published,

実験手法

ELECTRON MICROSCOPY (3.77 Å)