9HYT

Crystal structure of the GFRaL receptor in complex with an inhibitory cyclic peptide

Summary for 9HYT

• Entry DOI: 10.2210/pdb9hyt/pdb
• Descriptor: GDNF family receptor alpha-like, Inhibitory cyclic peptide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: gfral, gfralpha-like, gdf15, ret, inhibitor, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 89871.85

Authors

Sandmark, J.,Ek, M. (deposition date: 2025-01-10, release date: 2025-10-22)

• Primary citation: Noisier, A.F.M.,Sandmark, J.,Edfeldt, F.,Backmark, A.,Broddefalk, J.,Wandzik, J.,Jurva, U.,Ek, M.,Johansson, C.A.,Barlind, L.,Gunnarsson, J.,Bigalke, J.M.,Xue, Y.,Frolov, A.I.,Kankkonen, C.,Roth, R.G.,Fritsch, M.,Watcham, S.,van Rietschoten, K.,Mudd, G.E.,Harrison, H.,Chen, L.,Skynner, M.J.,Craik, D.J.,Chankeshwara, S.V.,Lemurell, M.; Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling; J.Med.Chem., 2025; DOI: 10.1021/acs.jmedchem.5c01378

Experimental method

X-RAY DIFFRACTION (1.9 Å)