9HXA

In vitro grown K58N Alpha-Synuclein Fibrils

Summary for 9HXA

• Entry DOI: 10.2210/pdb9hxa/pdb
• Related: 9HGR
• EMDB information: 52458
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-synuclein, k58n mutation, fibrils, cryo-em, protein aggregation, amyloid structure, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 28922.06

Authors

Sicking, K.,Al-Azzani, M.,Outeiro, T.F.,Fernandez-Busnadiego, R. (deposition date: 2025-01-07, release date: 2025-02-12, Last modification date: 2026-07-29)

Primary citation

Al-Azzani, M.,Weber, S.,Ramalingam, N.,Ramon, M.,Shvachiy, L.,Mestre, G.,Zech, M.,Sicking, K.,de Opakua, A.I.,Jayanthi, V.,Amaral, L.,Agarwal, A.,Chandran, A.,Chaves, S.R.,Winkelmann, J.,Trenkwalder, C.,Schwager, M.,Pauli, S.,Dettmer, U.,Fernandez, C.O.,Lautenschlager, J.,Zweckstetter, M.,Fernandez-Busnadiego, R.,Mollenhauer, B.,Outeiro, T.F.
A Novel alpha-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.
Mov Disord, 40:2732-2745, 2025

PubMed Abstract: Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α-synuclein (aSyn), are linked to rare familial forms of PD.

PubMed: 40905240
DOI: 10.1002/mds.70030

Experimental method

ELECTRON MICROSCOPY (3.7 Å)