9HX4

Amyloid fibril of apolipoprotein A-IV

Summary for 9HX4

• Entry DOI: 10.2210/pdb9hx4/pdb
• EMDB information: 52457
• Descriptor: Apolipoprotein A-IV (1 entity in total)
• Functional Keywords: amyloid, apolipoprotein, fibril, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 454339.61

Authors

Aibara, S.,Kassner, A.,Wong, E.,Klingel, K.,Papworth, M.,Althage, M.,Wang, Q.D.,Correia, C.,Milting, H.,Oliveira, T.M. (deposition date: 2025-01-06, release date: 2025-11-05)

Primary citation

Aibara, S.,Kassner, A.,Wong, E.,Klingel, K.,Papworth, M.,Althage, M.,Wang, Q.D.,Correia, C.,Milting, H.,de Oliveira, T.M.
Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis.
Nat Commun, 16:9276-9276, 2025

PubMed Abstract: Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient's heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.

PubMed: 41115976
DOI: 10.1038/s41467-025-64902-0

Experimental method

ELECTRON MICROSCOPY (3.3 Å)