9HPW

Crystal structure of meropenem bound to OXA-57

Summary for 9HPW

• Entry DOI: 10.2210/pdb9hpw/pdb
• Descriptor: Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: class-d beta-lactamase complex with a carbapenem, antimicrobial protein
• Biological source: Burkholderia pseudomallei
• Total number of polymer chains: 1
• Total formula weight: 27419.01

Authors

Bragginton, E.C.,Hinchliffe, P.,Spencer, J. (deposition date: 2024-12-16, release date: 2025-12-24)

• Primary citation: Bragginton, E.C.,Colenso, C.K.,Calvopina, K.,Hinchliffe, P.,Shaw, J.M.,Tooke, C.L.,Seng, R.,Chantratita, N.,Schofiled, C.J.,Spencer, J.; Structure and dynamics of Burkholderia pseudomallei OXA-57, a distinctive low efficiency class D beta-lactamase with carbapenem-hydrolyzing activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.42 Å)