9HMS

Cryo-EM structure of human separase bound to SCC1 (310-550 aa) and SA2

Summary for 9HMS

• Entry DOI: 10.2210/pdb9hms/pdb
• Related: 9HM7 9HMA
• EMDB information: 52288 52290 52297
• Descriptor: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, Separin, ... (4 entities in total)
• Functional Keywords: separase, cell cycle, scc1, rad21, protease, chromosome segregation, auto-cleavage, sa1/2, cohesin
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 411575.39

Authors

Yu, J.,Schmidt, S.,Botto, M.,Boland, A. (deposition date: 2024-12-09, release date: 2025-09-03)

• Primary citation: Yu, J.,Schmidt, S.,Botto, M.,Ghent, C.M.,Morgan, D.O.,Boland, A.; Structural insights into cohesin cleavage by human separase; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.4 Å)