9HIC

K166 acetylated human muscle pyruvate kinase, isoform M2 (PKM2), in complex with FBP

Summary for 9HIC

• Entry DOI: 10.2210/pdb9hic/pdb
• Descriptor: Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: acetylation, post-translational modification, glycolysis, genetic code expansion, acetylated lysine, metabolism, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 237029.08

Authors

Pavlenko, D.,Nudelman, H.,Shahar, A.,Arbely, E. (deposition date: 2024-11-25, release date: 2025-11-05)

• Primary citation: Pavlenko, D.,Tamargo-Azpilicueta, J.,Ankri, Y.,Nudelman, H.,Shahar, A.,Diez-Moreno, I.,Arbely, E.; Isoform-specific regulation of PKM by acetylation; Proc.Natl.Acad.Sci.USA, 2025

Experimental method

X-RAY DIFFRACTION (2.9 Å)