9H34

T2R-TTL-PROTAC1 complex

This is a non-PDB format compatible entry.

Summary for 9H34

• Entry DOI: 10.2210/pdb9h34/pdb
• Related: 9H30 9H31 9H32 9H33
• Descriptor: Tubulin alpha-1B chain, GLYCEROL, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 4-{2-[4-({2-[2-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)ethoxy]ethoxy}methyl)-1H-1,2,3-triazol-1-yl]ethyl}benzoate, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265868.18

Authors

Maiocchi, A.,Abel, A.-C.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (deposition date: 2024-10-15, release date: 2025-10-29)

• Primary citation: Maiocchi, A.,Abel, A.-C.,Basellini, M.,Perez Pena, H.,Boiarska, Z.,Ferrandi, E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Prota, A.E.,Passarella, D.; Effective tubulin degradation by rationally designed Proteolysis Targeting Chimeras; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)