9GUC

Adhiron-mediated Identification of a Novel and Selective Allosteric Pocket in Aurora Kinase A

Summary for 9GUC

• Entry DOI: 10.2210/pdb9guc/pdb
• Descriptor: Aurora kinase A, Affimer (JR-Aff7), ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: kinase, inhibitor, affimer, complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 45701.15

Authors

Roberts, J.P.,Miles, J.A.,Blinkhorne, F.,Gaule, T.G.,Bayliss, R.W.,Johnson, C.A.,Tomlinson, D.C. (deposition date: 2024-09-19, release date: 2025-10-01)

• Primary citation: Roberts, J.P.,Holder, J.,Miles, J.A.,Blinkhorne, F.,Tiede, C.,Gaule, T.G.,Cordell, P.A.,Mohan, I.,Shami-Inkindi, G.B.,Smith, C.E.,Bayliss, R.W.,Johnson, C.A.,Tomlinson, D.C.; Identification of the Novel, Druggable T-Pocket on Aurora Kinase A: Revealing a Selective Mechanism of Affimer mediated Allosteric Kinase Inhibition; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)