9GJ2
Crystal structure of human cathepsin S produced in insect cells in complex with ketoamide 13b
Summary for 9GJ2
Entry DOI | 10.2210/pdb9gj2/pdb |
Related | 8PRX |
Descriptor | Cathepsin S, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | cysteine protease, drug target, thiohemiketal, main protease inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 55309.80 |
Authors | Falke, S.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Reinke, P.Y.A.,Guenther, S.,Turk, D.,Meents, A. (deposition date: 2024-08-20, release date: 2024-09-04) |
Primary citation | Falke, S.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Reinke, P.Y.A.,Guenther, S.,Turk, D.,Meents, A. Crystal structure of human cathepsin S produced in insect cells in complex with ketoamide 13b To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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