9GHS

Crystal Structure of EGFR-WT in Complex with Covalent Compound 10a

This is a non-PDB format compatible entry.

Summary for 9GHS

• Entry DOI: 10.2210/pdb9ghs/pdb
• Descriptor: Epidermal growth factor receptor, (~{N}~{E})-2-(1-methylpyrazol-4-yl)-~{N}-[3-[(3~{R})-1-propanoylazepan-3-yl]-1~{H}-benzimidazol-2-ylidene]pyridine-4-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: egfr, wt, exon20, covalent, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38542.54

Authors

Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2024-08-16, release date: 2026-03-04)

• Primary citation: Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Grabe, B.,Koska, S.,Zischinsky, M.,Unger, A.,Weisner, J.,Arndt, A.,Mueller, M.P.,Rauh, D.; Selective Targeting of EGFR-Exon20 Insertion Mutations in Non-Small Cell Lung Cancer with Nazartinib and BI-4020 Inspired Hybrid Inhibitors; to be published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)