9GGA

Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer FM089

This is a non-PDB format compatible entry.

Summary for 9GGA

• Entry DOI: 10.2210/pdb9gga/pdb
• Descriptor: 14-3-3 protein sigma, Microtubule-associated protein tau, 2-bromanyl-4-[[(3~{R})-3-oxidanyl-3,4-dihydro-2~{H}-quinolin-1-yl]sulfonyl]benzaldehyde, ... (4 entities in total)
• Functional Keywords: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28475.75

Authors

van den Oetelaar, M.C.M.,Brunsveld, L.,Ottmann, C. (deposition date: 2024-08-13, release date: 2025-08-27)

• Primary citation: van den Oetelaar, M.C.M.,Ravatt, L.,Maqueda Zelaya, F.,Oberheide, A.O.,van de Wijngaart, T.R.,van Veldhuisen, T.W.,van Boxtel, F.M.A.,Verhoef, C.J.A.,Cossar, P.J.,Wegmann, S.,Ottmann, C.,Brunsveld, L.; Modulation of Tau Condensation with 14-3-3/Tau Molecular Glues; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.24 Å)