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9GFX

Huma Carbonic anhydrase II in complex with trans-2-phenylvinylboronic acid

This is a non-PDB format compatible entry.
Summary for 9GFX
Entry DOI10.2210/pdb9gfx/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, tris(oxidanyl)-[(~{E})-2-phenylethenyl]boron, ... (5 entities in total)
Functional Keywordscarbonic anhydrase ii, protein-inhibitor complex, inhibitor, boronic acid, lyase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight29611.54
Authors
Alterio, V.,De Simone, G.,Esposito, D. (deposition date: 2024-08-12, release date: 2024-11-06, Last modification date: 2024-11-13)
Primary citationEsposito, D.,Monti, S.M.,Supuran, C.T.,Winum, J.Y.,De Simone, G.,Alterio, V.
Exploring the binding mode of phenyl and vinyl boronic acids to human carbonic anhydrases.
Int.J.Biol.Macromol., 282:136873-136873, 2024
Cited by
PubMed Abstract: Boronic acids are an interesting but still poorly studied class of carbonic anhydrase inhibitors. Previous investigations proved that derivatives incorporating aromatic, arylalkyl, and arylalkenyl moieties are low micromolar to millimolar inhibitors for several α- and β-CAs involved in pathologic states. Here we report a high-resolution X-ray study on two classes of boronic acids (phenyl and vinyl) in complex with hCA II. Our results unambiguously clarify the binding mode of these molecules to the human carbonic anhydrase active site, which occurs through their tetrahedral anionic form, regardless of the nature of the organic scaffold. Data here presented contribute to the understanding of the inhibition mechanism of boronic acids that can be fruitfully used for the rational design of novel and effective isozyme-specific carbonic anhydrase inhibitors.
PubMed: 39454912
DOI: 10.1016/j.ijbiomac.2024.136873
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation

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PDB entries from 2024-11-20

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