9GEJ

Crystal structure of CREBBP bromodomain in complex with (2R,13S,E)-2-methyl-1,2,3,5,10,11,13,14,20,21,24,25-dodecahydro-19H,23H-16,18-etheno-9,13-methano-7,28-(metheno)[1,4]diazepino[2,3-k]pyrido[1,2-s][1,4]dioxa[7,19]diazacyclodocosine-4,8-dione

This is a non-PDB format compatible entry.

Summary for 9GEJ

• Entry DOI: 10.2210/pdb9gej/pdb
• Descriptor: CREBBP, 2R,13S,E)-2-methyl-1,2,3,5,10,11,13,14,20,21,24,25-dodecahydro-19H,23H-16,18-etheno-9,13-methano-7,28-(metheno)[1,4]diazepino[2,3-k]pyrido[1,2-s][1,4]dioxa[7,19]diazacyclodocosine-4,8-dione, SULFATE ION, ... (4 entities in total)
• Functional Keywords: bromodomain, protein-inhibitor complex, macrocycle, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 104236.55

Authors

Amann, M.,Boyd, A.,Einsle, O.,Guenther, S.,Moroglu, M.,Conway, S. (deposition date: 2024-08-07, release date: 2025-08-20)

• Primary citation: Amann, M.,Boyd, A.,Einsle, O.,Guenther, S.,Moroglu, M.,Conway, S.; Crystal structure of CREBBP bromodomain in complex with (2R,13S,E)-2-methyl-1,2,3,5,10,11,13,14,20,21,24,25-dodecahydro-19H,23H-16,18-etheno-9,13-methano-7,28-(metheno)[1,4]diazepino[2,3-k]pyrido[1,2-s][1,4]dioxa[7,19]diazacyclodocosine-4,8-dione; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.84 Å)