9GAO

Crystal structure of CRBNmidi in complex with 2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)-N-methylacetamide

This is a non-PDB format compatible entry.

Summary for 9GAO

• Entry DOI: 10.2210/pdb9gao/pdb
• Related: 8RQ1 8RQ8 8RQA
• Descriptor: Protein cereblon, 2-[4-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]phenoxy]-~{N}-methyl-ethanamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: e3 ligase, protac, tpd, molecular glue, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75641.00

Authors

Rutter, Z.J.,Kroupova, A.,Zollman, D.,Ciulli, A. (deposition date: 2024-07-29, release date: 2024-10-02)

• Primary citation: Rutter, Z.J.,Kroupova, A.,Zollman, D.,Ciulli, A.; Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)