9G5J

Structure of the PRO-PRO endopeptidase (PPEP-3) E153A Y189F in complex with substrate peptide Ac-EPLPPPP-NH2 from Geobacillus thermodenitrificans

Summary for 9G5J

Entry DOI	10.2210/pdb9g5j/pdb
Related	9G0J 9G3T
Descriptor	ATLF-like domain-containing protein, ACE-GLU-PRO-LEU-PRO-PRO-PRO-PRO-NH2, ZINC ION, ... (6 entities in total)
Functional Keywords	endopeptidase, metalloprotease, zinc, hydrolase
Biological source	Geobacillus thermodenitrificans NG80-2 More
Total number of polymer chains	8
Total formula weight	108915.57
Authors	Claushuis, B.,Wojtalla, F.,van Leeuwen, H.,Corver, J.,Baumann, U.,Hensbergen, P. (deposition date: 2024-07-17, release date: 2025-07-30, Last modification date: 2026-02-04)
Primary citation	Claushuis, B.,Wojtalla, F.,Papenhagen, L.,Cordfunke, R.A.,de Ru, A.H.,van Leeuwen, H.C.,Corver, J.,Hensbergen, P.J.,Baumann, U. Structural analyses and substrate profiling of PPEP-3 provide new insights into the molecular basis of Pro-Pro endopeptidase specificity Iscience, 29:114360-, 2026 Cited by DOI: 10.1016/j.isci.2025.114360 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation