9G4Y

TRPC5 in complex with photoswitch E-AzHC

This is a non-PDB format compatible entry.

Summary for 9G4Y

• Entry DOI: 10.2210/pdb9g4y/pdb
• EMDB information: 51074
• Descriptor: Short transient receptor potential channel 5, 8-[3-chloranyl-4-[(~{E})-phenyldiazenyl]phenoxy]-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (2 entities in total)
• Functional Keywords: photo-switch, inhibitor, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 358581.42

Authors

Porav, S.A.,Bon, R.,Muench, S. (deposition date: 2024-07-16, release date: 2025-07-30)

• Primary citation: Muller, M.,Niemeyer, K.,Ojha, N.K.,Porav, S.A.,Vinayagam, D.,Urban, N.,Buchau, F.,Oleinikov, K.,Makke, M.,Bauer, C.C.,Johnson, A.J.,Muench, S.P.,Zufall, F.,Bruns, D.,Schwarz, Y.,Raunser, S.,Leinders-Zufall, T.,Bon, R.S.,Schaefe, M.,Thorn-Seshold, O.; Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)