9G34

The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin

9G34 の概要

• エントリーDOI: 10.2210/pdb9g34/pdb
• 関連するPDBエントリー: 9FVO
• 分子名称: Endothiapepsin, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: aspartic protease, drug development, inhibitor, x-ray crystallographic screening, chestnut blight fungus, distinct unit cell, hydrolase
• 由来する生物種: Cryphonectria parasitica (chestnut blight fungus)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68987.35

構造登録者

Falke, S.,Senst, J.M.,Guenther, S.,Meents, A. (登録日: 2024-07-11, 公開日: 2024-07-24)

• 主引用文献: Falke, S.,Senst, J.M.,Guenther, S.,Meents, A.; The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin; To Be Published,

実験手法

X-RAY DIFFRACTION (1.3 Å)