9FTQ

Drosophila golgi alpha-mannosidase II (dGMII) in complex with swainsonine-configured alkyl indolizidine

This is a non-PDB format compatible entry.

Summary for 9FTQ

• Entry DOI: 10.2210/pdb9ftq/pdb
• Descriptor: Alpha-mannosidase 2, DI(HYDROXYETHYL)ETHER, swainsonine-configured alkyl indolizidine, ... (5 entities in total)
• Functional Keywords: inhibitor, glycosyl hydrolase, hydrolase
• Biological source: Drosophila melanogaster (fruit fly)
• Total number of polymer chains: 1
• Total formula weight: 118757.04

Authors

Bennett, M.,Koemans, T.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2024-06-25, release date: 2024-10-09)

• Primary citation: Koemans, T.,Bennett, M.,Ferraz, M.J.,Armstrong, Z.,Artola, M.,Aerts, J.M.F.G.,Codee, J.D.C.,Overkleeft, H.S.,Davies, G.J.; Structure-guided design of C3-branched swainsonine as potent and selective human Golgi alpha-mannosidase (GMII) inhibitor.; Chem.Commun.(Camb.), 2024; PubMed: 39318342; DOI: 10.1039/d4cc04514a

Experimental method

X-RAY DIFFRACTION (2.47 Å)