9FSV

Yeast 20S proteasome with human beta2i (1-53) in complex with epoxyketone inhibitor 42

This is a non-PDB format compatible entry.

Summary for 9FSV

• Entry DOI: 10.2210/pdb9fsv/pdb
• Related: 5CZ4
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (20 entities in total)
• Functional Keywords: proteasome, mutant, human chimeric subunit, structure-based drug development, inhibitor, binding analysis, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 28
• Total formula weight: 733650.24

Authors

Maurits, E.,Huber, E.M.,Dekker, P.M.,Wang, X.,Heinemeyer, W.,Florea, B.I.,Groll, M.,Overkleeft, H.S. (deposition date: 2024-06-22, release date: 2024-07-17, Last modification date: 2024-10-09)

• Primary citation: Maurits, E.,Huber, E.M.,Dekker, P.M.,Wang, X.,Heinemeyer, W.,Florea, B.I.,Groll, M.,Overkleeft, H.S.; Structure-based design of peptide epoxyketones selectively targeting the three human immunoproteasome active sites; to be published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)