9FRP

Human PARP10 ART domain bound to a phthalazinone-based inhibitor.

This is a non-PDB format compatible entry.

Summary for 9FRP

• Entry DOI: 10.2210/pdb9frp/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP10, 4-[[4-fluoranyl-3-[[(5~{S})-5-methyl-3-(1,3-thiazol-2-yl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: mono-adp-ribosyltransferase, parp10, kinase regulation, nuclear protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46147.42

Authors

Moche, M.,Upadhayaya, K.,Cohen, M.S.,Schuler, H. (deposition date: 2024-06-19, release date: 2026-01-14)

• Primary citation: Moche, M.,Upadhayay, K.,Cohen, M.S.,Schuler, H.; Human PARP10 ART domain bound to a phthalazinone-based inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)