9FEH

Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor

This is a non-PDB format compatible entry.

Summary for 9FEH

• Entry DOI: 10.2210/pdb9feh/pdb
• Descriptor: Transcription factor ETV6,Guanine-N7 methyltransferase nsp14, ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: viral, sars-cov-2, covid-19, methyltransferase, rna cap, inhibitor, stm957, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 1
• Total formula weight: 36181.45

Authors

Zilecka, E.,Klima, M.,Boura, E. (deposition date: 2024-05-20, release date: 2024-08-28, Last modification date: 2024-09-04)

• Primary citation: Zilecka, E.,Klima, M.,Stefek, M.,Dejmek, M.,Nencka, R.,Boura, E.; Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39.; J Struct Biol X, 10:100109-100109, 2024; PubMed: 39188530; DOI: 10.1016/j.yjsbx.2024.100109

Experimental method

X-RAY DIFFRACTION (1.99 Å)