9FBL

Structure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 15 discovered by high-throughput screening

This is a non-PDB format compatible entry.

Summary for 9FBL

• Entry DOI: 10.2210/pdb9fbl/pdb
• Descriptor: Casein kinase II subunit alpha, Cyclic peptidomimetic compound FMP35, NICOTINIC ACID, ... (6 entities in total)
• Functional Keywords: human protein kinase ck2 catalytic subunit alpha, csnk2a1 gene product, inhibition of ck2alpha/ck2beta subunit interaction, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 128899.04

Authors

Werner, C.,Niefind, K.,Eimermacher, S.,Pietsch, M.,Lindenblatt, D. (deposition date: 2024-05-14, release date: 2025-06-11, Last modification date: 2026-07-01)

• Primary citation: Werner, C.,Eimermacher, S.,Lauwers, M.,Lindenblatt, D.,Seymen, E.,Kulko, E.,Klein, L.,Steinkruger, M.,Baumann, R.,Salamon, S.,Fried, C.,Fischer, D.,Oder, A.,Neuenschwander, M.,Goetz, C.,Niefind, K.,Pietsch, M.; Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2 alpha 2 beta 2 holoenzyme; Rsc Chem Biol, 2026; DOI: 10.1039/D6CB00095A

Experimental method

X-RAY DIFFRACTION (2.18 Å)