9FBI

Structure of human protein kinase CK2 catalytic subunit (CK2alpha', CSNK2A2 gene product) in complex with the cyclic peptidomimetic compound 12 discovered by high-throughput screening

This is a non-PDB format compatible entry.

Summary for 9FBI

• Entry DOI: 10.2210/pdb9fbi/pdb
• Descriptor: Casein kinase II subunit alpha', Cyclic peptidomimetic compound FMP37, NICOTINIC ACID, ... (7 entities in total)
• Functional Keywords: human protein kinase ck2 catalytic subunit alpha', csnk2a2 gene product, inhibition of ck2alpha/ck2beta subunit interaction, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 87540.51

Authors

Niefind, K.,Werner, C.,Pietsch, M.,Eimermacher, S.,Lindenblatt, D. (deposition date: 2024-05-14, release date: 2025-06-11, Last modification date: 2026-07-01)

• Primary citation: Werner, C.,Eimermacher, S.,Lauwers, M.,Lindenblatt, D.,Seymen, E.,Kulko, E.,Klein, L.,Steinkruger, M.,Baumann, R.,Salamon, S.,Fried, C.,Fischer, D.,Oder, A.,Neuenschwander, M.,Goetz, C.,Niefind, K.,Pietsch, M.; Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2 alpha 2 beta 2 holoenzyme; Rsc Chem Biol, 2026; DOI: 10.1039/D6CB00095A

Experimental method

X-RAY DIFFRACTION (1.161 Å)