9FAP

CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1)

Summary for 9FAP

• Entry DOI: 10.2210/pdb9fap/pdb
• EMDB information: 50277
• Descriptor: Gamma-aminobutyric acid receptor subunit alpha-1, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... (20 entities in total)
• Functional Keywords: gaba, neurotransmission, ternary complex, inhibitory postsynapse, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 338438.64

Authors

Kasaragod, V.B.,Aricescu, A.R. (deposition date: 2024-05-10, release date: 2025-07-02)

• Primary citation: Kasaragod, V.B.,Aricescu, A.R.; CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1); To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)