9FAP

CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1)

Summary for 9FAP

Entry DOI	10.2210/pdb9fap/pdb
EMDB information	50277
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... (20 entities in total)
Functional Keywords	gaba, neurotransmission, ternary complex, inhibitory postsynapse, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	338438.64
Authors	Kasaragod, V.B.,Aricescu, A.R. (deposition date: 2024-05-10, release date: 2025-07-02)
Primary citation	Kasaragod, V.B.,Aricescu, A.R. CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1) To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation