9FAM

CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD3)

Summary for 9FAM

Entry DOI	10.2210/pdb9fam/pdb
EMDB information	50275
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (19 entities in total)
Functional Keywords	gaba, neurotransmission, ternary complex, inhibitory postsynapse, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	337780.52
Authors	Kasaragod, V.B.,Aricescu, A.R. (deposition date: 2024-05-10, release date: 2025-07-02)
Primary citation	Kasaragod, V.B.,Aricescu, A.R. CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody in a desensitised state (StateD3) To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation