9F8G
Photostatin (photoswitchable azo-combretastatin) Z-PST27 bound to tubulin-DARPin D1 complex
This is a non-PDB format compatible entry.
Summary for 9F8G
Entry DOI | 10.2210/pdb9f8g/pdb |
Descriptor | Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ... (8 entities in total) |
Functional Keywords | tubulin polymerisation inhibitor, microtubule dynamics, antimitotics, photopharmacology, photoswitch, sensitisation, cell cycle |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 3 |
Total formula weight | 119706.20 |
Authors | |
Primary citation | Reynders, M.,Garscia, M.,Muller-Deku, A.,Wranik, M.,Krauskopf, K.,de la Osa de la Rosa, L.,Schaffer, K.,Jotten, A.,Rode, A.,Stierle, V.,Kraus, Y.,Baumgartner, B.,Ali, A.,Bubeneck, A.,Seal, T.,Steinmetz, M.O.,Paulitschke, P.,Thorn-Seshold, O. A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol. Chem Sci, 15:12301-12309, 2024 Cited by PubMed: 39118608DOI: 10.1039/d4sc03072a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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